In addition to routine chromosome studies, the Center for Human Genetics offers the following cancer cytogenetic FISH panels:
FISH Panels
Acute Myeloid Leukemia (AML)
Gene specific probe loci |
Structural Chromosome Abnormality |
AML subtype |
ETO/AML1 |
t(8;21)(q22;q22) |
M2 |
PML/RARA |
t(15;17)(q22;q21) |
M3 |
CBFbeta |
inv(16);t(16;16) |
M4, Eos |
Cen8/MYC |
+8 (Trisomy 8) |
M0-M7 |
DEK/CAN |
t(6;9)(p23;q34) |
M2, M4, M1 |
EVI1 |
3q26 rearrangements |
M1, 2, 4, 6, 7 |
MLL |
11q23 rearrangements |
M0-M7 |
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
TEL/AML1 |
t(12;21)(p13;q22) |
|
BCR/ABL/ASS |
t(9;22)(q34;q11.2) |
|
PBX1/TCF3 |
t(1;19)(q23;p13.3) |
|
CDKN2A/CEN9 |
del(9)(p21) |
|
4cen |
+4 (Trisomy 4) |
|
10cen |
+10 (Trisomy 10) |
|
17cen |
+17 (Trisomy 17) |
|
MLL |
11q23 rearrangements |
|
Chronic Lymphocytic Leukemia (CLL)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
c-MYB/6cen |
-6/6q deletion |
|
ATM/11cen |
-11/11q deletion |
|
12 cen |
+12 (Trisomy 12) |
|
D13S319/LAMP1 |
-13/13q deletion |
|
p53/17cen |
-17/17p deletion |
|
CCND1/IGH |
t(11;14)(q13;q32) |
|
Chronic Myelogenous Leukemia (CML)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
BCR/ABL/ASS |
t(9;22)(q34;q11.2) |
|
Chronic myelomonocytic leukemia (CMML)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
EGR1/D5S23,D5S721 |
-5/5q deletion |
|
D7S486/7cen |
del(7)(q31) |
|
Cen8/MYC |
+8 (Trisomy 8) |
|
BCR/ABL/ASS |
t(9;22)(q34;q11.2) |
|
D20S108/D20S150 |
20q12 deletion |
|
Imatinib Mesylate (Gleevec) Responsive Genes
Gene specific probe loci |
Structural Chromosome Abnormality |
|
PDGFRB |
5q32-q33 |
|
FLP1L1/PDGFRA |
4q12 |
|
BCR/ABL/ASS |
t(9;22)(q34;q11.2) |
|
Lymphoma
Gene specific probe loci |
Structural Chromosome Abnormality |
|
MYC |
8q24 rearrangements |
|
MYC/IGH/CEP8 |
t(8;14)(q24;q32) |
|
BCL2/IGH |
t(14;18)(q32;q21) |
|
BCL6 |
3q27 rearrangements |
|
CCND1/IGH |
t(11;14)(q13;q32) |
|
MALT1 |
18q21 rearrangements |
|
*MALT1/IGH |
t(14;18)(q32;q21) |
|
*MALT reflex if ordered
Multiple Myeloma (MM) and Plasma Cell Proliferative disorders (PCPD)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
IGH |
14q32 rearrangements |
|
CCND1/IGH |
t(11;14)(q13;q32) |
|
p53/17cen |
-17/17p deletion |
|
RB1/LAMP1 |
-13/13q deletion |
|
9cen/15cen |
+9 and +15 |
|
cen/7cen |
+3 and +7 |
|
Myelodysplastic Syndrome (MDS)
Gene specific probe loci |
Structural Chromosome Abnormality |
|
EGR1/D5S23,D5S721 |
-5/5q deletion |
|
7cen/D7S486 |
-7/7q deletion |
|
8cen/MYC |
+8 (Trisomy 8) |
|
D13S319/LAMP1 |
-13/13qdeletion |
|
D20S108/20qter |
-20/20q deletion/idic(20q) |
|
EVI1 |
3q26 rearrangements |
|
Other Hematologic Tests
Gene specific probe loci |
Structural Chromosome Abnormality |
|
MYB |
6q23 |
|
MYC |
8q24 rearrangements |
|
p53 |
17p13 deletion |
|
FLP1-L1/PDGFRA |
4q12 rearrangements/tri-color rearrangements |
|
Sex mismatched bone marrow transplant |
|
|
Other gene/locus chromosome anomalies (please specify) |
|
BCR/ABL/ASS |
t(9;22)(q34;q11.2) |
|
MLL |
11q23 rearrangements |
|